مقاله پیشرفت درمان در بیماری اچ آی وی به زبان انگلیسی

مقاله پیشرفت درمان در بیماری اچ آی وی و استراتژی های ضد ویروسی جدید به زبان انگلیسی

Treatment Advances in HIV Disease and New Antiretroviral Strategies - Michael Johnson, M.D.

چکیده:

When somebody is initially infected with HIV there is rapid viral replications, so that within a few weeks of getting infected there is a very large amount of virus in the blood.  At the same time the CD4 cell count drops rapidly and during this period of time the person may well have a mononucleosis like illness characterized by fever, lymphadenopathy, headaches, rash, and diarrhea.  Eventually the immune system takes over to some degree and the CD4 cell count comes back up often not to the same levels it was at before, but it certainly rises from where it was during the acute infection.  The amount of virus in the bloodstream comes down.  The person at this point then enters a period of clinical latency after the acute infection.  This period can last on an average somewhere between 8 and 10 years, so there is wide variability. During this period of time the person feels completely well.  There is nothing you can find on exam to show HIV infection, the virus is anything but latent during this period.  HIV is replicating very rapidly at every stage of HIV infection, including during this period of clinical latency.  About 10 billion new variants are produced every day in an HIV infected person.  This is somebody who is feeling completely fine and every day; they turn out 10 billion new HIV particles.  The half-life of these particles is a very small, 6 hours, so that there is just a constant production and destruction of HIV in the bloodstream.  Along with the CD4 cells, which are one of the main targets of HIV infection, being produced and destroyed at 10 to 100 times the normal rate.  There is really an ongoing battle going on between HIV production and destruction, even while the patient is feeling really completely well.

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